Different effects of glucagon and epinephrine on the kinetic properties of liver glycogen synthase

FEBS Letters

Bosch, Fàtima¹  Ciudad, Carlos J.¹  Guinovart, Joan J.¹ 

[1] Department de Bioquímica, Facultat de Farmàcia, Universitat de Barcelona, Pedralbes, Barcelona-28, Spain

关键词: Glycogen synthase;    Epinephrine;    Glucagon;    Rat hepatocyte;   

DOI  :  10.1016/0014-5793(83)80346-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Kinetic constants of glygocen synthase (S _0.5 for glucose-6-P and M _0.5 for UDP-glucose) were determined after hepatocytes isolated from starved rats were incubated with either glucagon or epinephrine. Incubation with these hormones resulted in an increase in both S _0.5 and M _0.5. However, the action of glucagon resulted in great modifications on S _0.5 whereas epinephrine affected mainly M _0.5. Therefore, glucagon and epinephrine alter the kinetic properties of glycogen synthase provoke the phosphorylation of glycogen synthase at different site(s) acting through different mechanisms.

【 授权许可】

Unknown