Inactivation of basal glycogen synthase by glucagon and epinephrine in hepatocytes from fed rats

FEBS Letters

Bosch, Fàtima¹  Ciudad, Carles J.¹  Guinovart, Joan J.¹ 

[1] Department of Biochemistry, Autonomous University of Barcelona, School of Veterinary Medicine, Bellaterra, Barcelona, Spain

关键词: (Rat hepatocyte) Glucagon Epinephrine Glycogen synthase;   

DOI  :  10.1016/0014-5793(86)80508-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Glucagon and epinephrine promote the inactivation of basal glycogen synthase in hepatocytes isolated from fed rats. However, this effect is only observable when the activation state of glycogen synthase is measured using the low glucose-6-P/high glucose-6-P activity ratio assay. This inactivation is the consequence of an increase in the kinetic parameters (S _0.5 for UDP-glucose and M _0.5 for glucose-6-P) of the enzyme. Therefore, this work demonstrates these hormones are also able to control glycogen synthase from fed animals.

【 授权许可】

Unknown