Adriamycin‐dependent damage to deoxyribose: a reaction involving iron, hydroxyl and semiquinone free radicals

FEBS Letters

Toeg, Daniel¹  Gutteridge, John M.C.¹ 

[1] Division of Antibiotics, National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RB, England

关键词: Deoxyribose degradation;    Thiobarbituric acid-reactivity;    Adriamycin semiquinone radical;    Hydroxyl radical;    Superoxide dismutase;    Desferrioxamine;   

DOI  :  10.1016/0014-5793(82)81106-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Adriamycin under partially anaerobic conditions degrades deoxyribose with the release of thiobarbituric acid-reactive products. This reaction is seen when electrons are transferred to adriamycin by xanthine oxidase or ferredoxin reductase to form the semiquinone free radical. Under the conditions described, damage to deoxyribose was inhibited by hydroxyl radicals scavengers, catalase and iron chelators. When the ratio of iron chelator to iron salt is varied both EDTA and diethylenetriamino penta-acetic acid (DETAPAC) show stimulatory properties whereas desferrioxamine remains a potent inhibitor of all reaction.

【 授权许可】

Unknown