Inhibition by dopamine of 86Rb efflux and hormone secretion from bovine anterior pituitary cells perifused in the presence of acetylcholine or TRH

FEBS Letters

Schofield, J.G.²  Bicknell, R.J.¹  Saith, S.² 

[1] A.R.C. Institute of Animal Physiology, Babraham, Cambridge CB2 4AT, England;Department of Biochemistry, University of Bristol, Bristol BS8 1TD England

关键词: Prolactin;    Growth hormone;    Thyroliberin;    Dopamine;    Anterior pituitary;    Potassium permeability;   

DOI  :  10.1016/0014-5793(82)81235-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effects of dopamine (10⁻⁵ M) on growth hormone and prolactin secretion and the fractional rate of ⁸⁶Rb efflux were investigated using perifused bovine pituitary cells. Dopamine decreased the control efflux rate, prevented the rise caused by thyroliberin (10⁻⁷ M) in the presence of 3-isobutyl-l-methyl-xanthine (10⁻⁴ M) and greatly decreased the rise caused by acetylcholine (2.5 × 10⁻⁵ M). Under these conditions it inhibited the prolactin secretion but it had no effect on growth hormone secretion induced by either treatment. Dopamine receptors in lactotrophs are therefore coupled to secretion and potassium permeability, but if somatotrophs contain dopamine receptors they are coupled only to K⁺ efflux.

【 授权许可】

Unknown