THE EFFECTS OF ENDOMETRIAL INJURY ON INTRAUTERINE INSEMINATION OUTCOME: A RANDOMIZED CLINICAL TRIAL (SHORT COMMUNICATION)

Iranian journal of reproductive medicine

ALBORZI SAEED¹  DADRAS NASRIN¹  ZAREI AFSOON¹  AZADI GHAZAL¹ 

关键词: INFERTILITY;    FEMALE;    ENDOMETRIAL INJURY;    PREGNANCY;    INTRAUTERINE INSEMINATION (IUI);   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Implantation is considered as the rate-limiting step in success of assisted reproduction techniques, and intrauterine insemination cycles. It might be affected by ovarian superovulation and endometrial local scratching.Objective: This study aims to investigate the effect of local endometrial injury on the outcome of IUI cycles.Materials and Methods: In this randomized clinical trial 144 women with unexplained infertility, mild male factor, and mild endometriosis randomly divided into two study groups through block randomization. The patients were randomly assigned to undergo endometrial biopsy between days 6-8 of the previous menstrual cycle before IUI (n=72, IUI cycles =126) or receive no interventions (n=72, IUI cycles=105).Results: The pregnancy rate per patient was 17 (23.6%) and 14 (19.4%) in endometrial biopsy and control groups, respectively (p=0.686). The pregnancy rate per cycle was 17/126 (13.5%) and 14/105 (13.3%) in endometrial biopsy and control groups, respectively (p=0.389). The abortion rate was comparable between the two groups (6.9% vs. 9.7%; p=0.764). The ongoing pregnancy rate was found to be comparable between the two study groups, as well (16.7% vs. 9.7%; p=0.325). Endometrial thickness (p=0.609) was comparable between the groups; however E2 was significantly lower in the endometrial biopsy group (p<0.001). Conclusion: Application of local endometrial injury in the cycle before the IUI cycles is not associated with increased pregnancy rate per patient and per cycle, decreased abortion, and increased endometrial thickness.

【 授权许可】

Unknown