EFFECTIVENESS OF ASPIRIN COMPARE WITH HEPARIN PLUS ASPIRIN IN RECURRENT PREGNANCY LOSS TREATMENT: A QUASI EXPERIMENTAL STUDY

Iranian journal of reproductive medicine

MOSTAFAVI MAHDIA SADAT¹  JAHANINEJAD TAHEREH¹  GHASEMI NASRIN¹  AFLATOONIAN ABBAS¹ 

关键词: THROMBOPHILIA;    RECURRENT MISCARRIAGE;    ANTICOAGULANT;    LIVE BIRTH;    ASPIRIN;    HEPARIN;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Using aspirin, heparin, or both in women with unexplained recurrent miscarriage could be useful, because this problem might be initiated by thrombosis in decidual vessels.Objective: To investigate the association between thrombophilia and unexplained recurrent miscarriage and to evaluate the efficacy of anticoagulant treatment.Materials and Methods: In this quasi experimental, we enrolled 520 women, who had a history of recurrent miscarriage. Two hundred fifty two women with unexplained recurrent miscarriage were assigned to receive aspirin (80 mg daily) for two month before pregnancy and after confirmation of a viable pregnancy until 36 weeks of gestation or receive aspirin, as the same, plus heparin (5000 unit twice a day) subcutaneously after confirmation of viable pregnancy until 4 weeks after delivery. Type of medication was chosen for each woman according to number of abortion and age.Results: Live-birth rates did not different significantly among the two study groups. The proportions of women who gave birth to a live normal infant were 74.5% in the group receiving aspirin plus heparin (combination-therapy group) and 79.8% in the aspirin group.Conclusion: Live-birth rates did not different significantly among the two study groups. So, using aspirin or aspirin plus heparin did not change pregnancy rate in these patients. Using aspirin is easier than injecting heparin which should be chosen case by case.

【 授权许可】

Unknown