GRANULOCYTE COLONY-STIMULATING FACTOR AND REPRODUCTIVE MEDICINE: A REVIEW

Iranian journal of reproductive medicine

BARINI RICARDO¹  CAVALCANTE MARCELO BORGES¹  SILVA COSTA FABRICIO DA¹  JUNIOR EDWARD ARAUJO¹ 

关键词: GRANULOCYTE COLONY-STIMULATING FACTOR;    IMMUNOTHERAPY;    RECURRENT MISCARRIAGE;    REPRODUCTIVE MEDICINE;    REVIEW;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Recently, the use of granulocyte colony-stimulating factor (G-CSF) has been proposed to improve pregnancy outcomes in reproductive medicine.Objective: A systematic review of the current use of G-CSF in patients who have difficulty conceiving and maintaining pregnancy was performed.Materials and Methods: Two electronic databases (PubMed/ Medline and Scopus) were searched. Study selection, data extraction and quality assessment were performed in duplicate. The subject codes used were granulocyte colony-stimulating factor, G-CSF, recurrent miscarriage, IVF failure, and endometrium.Results: The search of electronic databases resulted in 215 citations (PubMed/ Medline: 139 and Scopus: 76), of which 38 were present in both databases. Of the remaining 177 publications, seven studies were included in the present review.Conclusion: Treatment with G-CSF is a novel proposal for immune therapy in patients with recurrent miscarriage and implantation failure following cycles of IVF. However, a larger number of well-designed studies are required for this treatment to be established.

【 授权许可】

Unknown