Smoking Effect on Ischemic Heart Disease in Young Patients

Journal of Cardiovascular and Thoracic Research

Bassam Al-Halabi¹  Khaled Hbejan¹ 

[1] Department of Internal Medicine, Faculty ofMedicine, Aleppo University Heart Hospital, Syria.$$

关键词: Acute Coronary Syndrome;    Smoking;    Ischemic Heart Disease;   

DOI  :  

学科分类：农业科学（综合）

来源: Tabriz University of Medical Sciences and Health Services

【 摘 要 】

Background: Smoking predisposes individuals to several atherosclerotic clinical syndromes, including myocardialinfarction and other acute coronary syndromes, stable angina and sudden death. Smoking can trigger myocardial infarctionin individuals with minimal atherosclerosis or even with normal coronary arteries, especially among the young, promotingtemporary coronary vessel occlusion, as a result of thrombus formation, coronary artery spasm or both. This study aims toevaluate the effect of tobacco smoking on the risk of ischemic heart disease (ST elevation myocardial infarction, non STelevation myocardial infarction, unstable angina, and Prinzmetal`s angina) in young adults (�? 45 years).Methods: A retrospective study was conducted over a 2-year Period from January 2008 to March 2010. One hundred andthirty five consecutive cases of acute myocardial infarction (STEMI and NSTEMI), Unstable angina, and Prinzmetal`sangina in young patients (�? 45 years) who present to the emergency department (ED) of the Aleppo University Hospital,Aleppo University Heart Hospital, and admitted to the cardiovascular care unit (CCU). Data were compared betweensmoker patients and non smoker patients.Results: The mean age was 39.7±3 years (range20�?45), 87.60% were males. The major risk factor was tobacco use(78.48%), followed by hypertension (23.70%), dyslipidemia (21.48%), obesity (18.51%), family history of IHD (15.55%),and diabetes mellitus (3.7%). (56.6%) of patients had a smoking as a single risk factor for ischemic heart disease withoutanother risk factors. (59.25%) of patients had STEMI; (22.96%) had NSTEMI; (16.29%) had unstable angina; and (1.48%)had Prinzmetal`s angina. (56.89%) of patients had single vessel disease as documented by angiography; ( 20.68%) hadtow-vessel disease, (13.79%) had three-vessel disease ; and ( 8.62%) had normal coronary arteries.Conclusions: The study focuses our attention on the rising incidence of acute MI in young individuals. Smoking was themajor risk factor followed by hypertension, dyslipidemia, obesity, family history of IHD, and diabetes mellitus. Theseobservations are important for primary prevention of such diseases in young individuals.

【 授权许可】

Unknown