Chemistry Study on Protective Effect against ·OH-induced DNA Damage and Antioxidant Mechanism of Cortex Magnoliae Officinalis

Bulletin of the Korean chemical society

Xican Li¹  Qian Fang¹  Yaoxiang Gao¹  Zhengpeng Yuan¹  Jing Lin¹  Lu Han¹ 

关键词: Cortex Magnoliae Officinalis;    DNA damage;    Antioxidant;    Hydroxyl radical;    Phenylpropanoid;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

As a Chinese herbal medicine used in East Asia for thousands years, Cortex Magnoliae Officinalis (CMO) was observed to possess a protective effect against ·OH-induced DNA damage in the study. To explore the mechanism, the antioxidant effects and chemical contents of five CMO extracts were determined by various methods. On the basis of mechanistic analysis, and correlation analysis between antioxidant effects & chemical contents, it can be concluded that CMO exhibits a protective effect against ·OH-induced DNA damage, and the effect can be attributed to the existence of phenolic compounds, especially magnolol and honokiol. They exert the protective effect via antioxidant mechanism which may be mediated via hydrogen atom transfer (HAT) and/ or sequential electron proton transfer (SEPT). In the process, the phenolic –OH moiety in phenylpropanoids is oxidized to the stable quinine-like form and the stability of quinine-like can be ultimately responsible for the antioxidant.

【 授权许可】

Unknown