Synthesis of New Pyrimidinylaminobenzene Derivatives and Their Antiproliferative Activities against Melanoma Cell Line

Bulletin of the Korean chemical society

Kyung Ho Yoo¹  Chang-Hyun Oh¹  Hee Jin Kim¹ 

关键词: Antiproliferative activity;    Pyrimidinylaminobenzene;    Diarylamide;    Diarylurea;    Melanoma;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A series of new diarylamide and diarylurea derivatives possessing pyrimidinylaminobenzene scaffold was synthesized. Their in vitro antiproliferative activities were tested against A375P human melanoma cell line. Among them, compounds 1a-c, k and 2b-d, f, g, j, l showed superior potencies against A375P human melanoma cell line to Sorafenib. In particular, compound 2f possessing 3-fluoro-5-trifluoromethyl moiety exhibited the highest potency with IC50 value in nanomolar scale.

【 授权许可】

Unknown