期刊论文详细信息
Bulletin of the Korean chemical society | |
Synthesis of New Pyrimidinylaminobenzene Derivatives and Their Antiproliferative Activities against Melanoma Cell Line | |
Kyung Ho Yoo1  Chang-Hyun Oh1  Hee Jin Kim1  | |
关键词: Antiproliferative activity; Pyrimidinylaminobenzene; Diarylamide; Diarylurea; Melanoma; | |
DOI : | |
学科分类:化学(综合) | |
来源: Korean Chemical Society | |
【 摘 要 】
A series of new diarylamide and diarylurea derivatives possessing pyrimidinylaminobenzene scaffold was synthesized. Their in vitro antiproliferative activities were tested against A375P human melanoma cell line. Among them, compounds 1a-c, k and 2b-d, f, g, j, l showed superior potencies against A375P human melanoma cell line to Sorafenib. In particular, compound 2f possessing 3-fluoro-5-trifluoromethyl moiety exhibited the highest potency with IC50 value in nanomolar scale.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010244690ZK.pdf | 507KB | download |