期刊论文详细信息
Bulletin of the Korean chemical society | |
Synthesis and Antiproliferative Activity of New Aminoisoquinolinylurea Derivatives against Melanoma Cell Line | |
Jun Hee Hong1  So Ha Lee1  Kyung Ho Yoo1  Hong Seok Choi1  Garam Kim1  Hye Jung Cho1  Mohammed I. El-Gamal1  Chang-Hyun Oh1  | |
关键词: A375P; Aminoisoquinoline; Anticancer; Diarylurea; Melanoma; | |
DOI : | |
学科分类:化学(综合) | |
来源: Korean Chemical Society | |
【 摘 要 】
A series of new diarylureas possessing aminoisoquinoline scaffold was synthesized, and their in vitro antiproliferative activity against A375P human melanoma cell line was tested. Compounds 1d, 1l, 1n, 1p, 1q, and 1t showed superior potency against A375P to Sorafenib. The highest potency was shown by compound 1p possessing 3,5-bis(trifluoromethyl)phenyl terminal ring with IC50 value of 0.41 μM.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010243468ZK.pdf | 218KB | download |