Synthesis and Antiproliferative Activity of New Aminoisoquinolinylurea Derivatives against Melanoma Cell Line

Bulletin of the Korean chemical society

Jun Hee Hong¹  So Ha Lee¹  Kyung Ho Yoo¹  Hong Seok Choi¹  Garam Kim¹  Hye Jung Cho¹  Mohammed I. El-Gamal¹  Chang-Hyun Oh¹ 

关键词: A375P;    Aminoisoquinoline;    Anticancer;    Diarylurea;    Melanoma;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A series of new diarylureas possessing aminoisoquinoline scaffold was synthesized, and their in vitro antiproliferative activity against A375P human melanoma cell line was tested. Compounds 1d, 1l, 1n, 1p, 1q, and 1t showed superior potency against A375P to Sorafenib. The highest potency was shown by compound 1p possessing 3,5-bis(trifluoromethyl)phenyl terminal ring with IC50 value of 0.41 μM.

【 授权许可】

Unknown