Bulletin of the Korean chemical society | |
Design, Synthesis, and Preliminary Cytotoxicity Evaluation of New Diarylureas and Diarylamides Possessing 1,3,4-Triarylpyrazole Scaffold | |
Jun Hee Hong1  Won-Kyoung Choi1  Hong Seok Choi1  Daejin Baek1  Kihang Choi1  Mohammed I. El-Gamal1  Chang-Hyun Oh1  | |
关键词: A375P; Anticancer; Diarylamide; Diarylurea; 1; 3; 4-Triarylpyrazole; | |
DOI : | |
学科分类:化学(综合) | |
来源: Korean Chemical Society | |
【 摘 要 】
A series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3- (trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010244041ZK.pdf | 847KB | download |