Preparation and Characterization of PEG/PLA Multiblock and Triblock Copolymer

Bulletin of the Korean chemical society

Hesong Zhao¹  Sanghyuk Park¹  Sang-Ho Kim¹  Longhai Piao¹  Zhun Liu¹  Jung-Hyun Kim¹ 

关键词: Block copolymers;    Biodegradable;    Biopolymers;    Triblock;    Multiblock;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A series of poly (lactic acid) (PLA) and poly (ethylene glycol) (PEG) tri and multiblock copolymers with relatively high molecular weights were synthesized through the coupling reaction between the bis(acyl chloride) of carboxylated PLA and mono or dihydroxy PEG. The coupling reaction and the copolymer structures were monitored by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The melting temperature (Tm) of PEG blocks decreased with the presence of PLA sequences attaching to PEG blocks. The CMC values were determined to be 10-145 mg/L depending on the length of PLA and PEG blocks and the structure of the block copolymers.

【 授权许可】

Unknown