Synthesis, Characterization and Biological Evaluations of Ciprofloxacin Carboxamide Analogues

Bulletin of the Korean chemical society

Syeda Bushra Shakeb Rizvi¹  Muhammad Saeed Arayne¹  Urooj Haroon¹  Najma Sultana¹ 

关键词: Ciprofloxacin;    Ester aminolysis reaction;    Antibacterial activity;    Antifungal activity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Present work comprises of synthesis various analogues of ciprofloxacin by introducing new functionality at carboxylic group position via ester aminolysis reaction. For this purpose the carboxylic group at C-3 was esterified and later subjected to nucleophilic attack at the carbonyl carbon by various aromatic amines. Structure of the analogues was confirmed by different techniques i.e. IR, 1H NMR and mass spectrometry. The antibacterial activity of the derivatives was also assessed with the parent against a series of Gram-positive and Gram-negative bacteria. The synthesized compounds showed diverse antimicrobial profile among which most compounds possessed a comparable or better activity in comparison to the ciprofloxacin. Additionally unlike ciprofloxacin, some of the derivatives were also found to show antifungal activity.

【 授权许可】

Unknown