Bulletin of the Korean chemical society | |
Amphiphilic cyclotriphosphazenes grafted with branched oligopeptides | |
Jin Xin Cui1  Vithal B Jadhav1  Udaya S Toti1  Yong Joo Jun1  Youn Soo Sohn1  | |
关键词: Branched oligopeptide; Cyclotriphosphazenes; Micelles; | |
DOI : | |
学科分类:化学(综合) | |
来源: Korean Chemical Society | |
【 摘 要 】
Branched oligopeptides prepared by coupling a very hydrophobic aspartic diamino acid ethyl ester such as Asp (LeuEt)2, Asp(IleEt)2 and Asp(PheEt)2 to glycine or glycylphenylalanine were grafted to the cyclotriphosphazene backbone bearing an equimolar hydrophilic poly(ethylene glycol) (PEG). The properties of the resultant amphiphiles were examined in comparison with those of the linear oligopeptide analogues previously reported. All cyclic phosphazene trimers grafted with the branched tetra- and pentapeptides displayed a normal trend of thermosensitivity depending on their hydrophilic to hydrophobic balance, but the stability and particle size of their micelles were found to be greatly dependent on the fine structure of the branched oligopeptides grafted. The trimers bearing branched tetrapeptides with a low hydrophobicity were found to form unstable micelles initially, which reassemble into thermodynamically more stable polymersomes.
【 授权许可】
Unknown
【 预 览 】
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RO201912010242012ZK.pdf | 712KB | download |