Small angle neutron scattering study of doxorubicin–surfactant complexes encapsulated in block copolymer micelles

Pramana

P A Hassan1²  V K Aswal¹  Gunjan Verma²  Jayita Bhattacharjee² 

[1] Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India$$;Chemistry Division; Bhabha Atomic Research Centre, Mumbai 400 085, India$$

关键词: Micelles;    polymer solutions;    neutron scattering.;   

DOI  :  

学科分类：物理（综合）

来源: Indian Academy of Sciences

【 摘 要 】

Self-assembling behaviour of block copolymers and their ability to evade the immune system through polyethylene oxide stealth makes it an attractive candidate for drug encapsulation. Micelles formed by polyethylene oxide–polypropylene oxide–polyethylene oxide triblock copolymers (PEO–PPO–PEO), pluronic P123, have been employed for encapsulating the anti-cancer drug doxorubicin hydrochloride. The binding affinity of doxorubicin within the micelle carrier is enhanced through complex formation of drug and anionic surfactant, aerosol OT (AOT). Electrostatic binding of doxorubicin with negatively charged surfactants leads to the formation of hydrophobic drug–surfactant complexes. Surfactant-induced partitioning of the anti-cancer drug into nonpolar solvents such as chloroform is investigated. SANS measurements were performed on pluronic P123 mi-celles in the presence of drug–surfactant complex. No significant changes in the structure of the micelles are observed upon drug encapsulation. This demonstrates that surfactant–drug complexes can be encapsulated in block copolymer micelles without disrupting the structure of aggregates.

【 授权许可】

Unknown