Comparison of D-[18F]FMAU and L-[18F]FMAU as PET Imaging Agents for HSV1-TK Gene Expression

Bulletin of the Korean chemical society

Mohammed I El Gamal¹  Jin Hun Park¹  Jung Hyuck Cho¹  Won Kyoung Choi¹  Gwang Il An¹  Tae Hyun Choi¹  Gi Jeong Cheon¹  Su Hee Hong¹  Chang Hyun Oh¹  Nam Hyun Jo¹  Byung Seok Moon¹  Kyo Chul Lee¹ 

关键词: HSV1-TK;    D-[18F]FMAU;    L-[18F]FMAU;    PET imaging;    MicroPET;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

D-[18F]FMAU and L-[18F]FMAU are F-18 labeled nucleoside analogue which have been efficiently synthesized in order to be a PET imaging probe. D-[18F]FMAU and L-[18F]FMAU were compared as PET imaging agents using HSV1-TK gene expressing tumor-bearing mice. Their cellular uptake profiles were also compared using MCA and MCA-TK cell lines. D-[18F]FMAU demonstrated higher cellular uptake and higher accumulation in MCA-TK tumor regions than L-[18F]FMAU. On the other hand, L-[18F]FMAU showed higher MCA-TK/MCA ratio of %ID/g than that of D-[18F]FMAU. L-[18F]FMAU can be utilized as a good candidate for HSV1-TK PET imaging. It can be used for antiviral drug evaluation.

【 授权许可】

Unknown