The Inhibitory Effect of New Hydroxamic Acid Derivatives on Melanogenesis

Bulletin of the Korean chemical society

Heung Soo Baek¹  Soo Mi Ahn¹  Duck Hee Kim¹  Jin Young Lee¹  Jae Won Yoo¹  Jeonga-Lee¹  Ho Sik Rho¹  Min-Kee Kim¹  Ih Seop Chang¹ 

关键词: Hydroxamic acid;    Derivative;    Tyrosinase;    Melanogenesis;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The aim of present study was to examine the inhibitory effects of hydroxamic acid derivatives on the melanogenesis. We found that hydroxamic acid moiety was important for anti-melanogenic activity. Compounds 1a and 1b strongly inhibited melanin synthesis via deactivation of tyrosinase. Hydroxamic acid has metal ion chelating ability which is similar to that kojic acid, however, anti-tyrosinase mechanism of compounds 1a and 1b was different from that of kojic acid. They showed noncompetitive inhibition kinetics

【 授权许可】

Unknown