Modification of C11, C28, C2,3,23 or C2,23,28 Functional Groups on Asiatic Acid and Evaluation of Hepatoprotective Effects

Bulletin of the Korean chemical society

Eung-Seok Lee¹  Mi Kyeong Lee¹  Hyeung-geun Park¹  Pritam Thapa¹  Radha Karki¹  Long-Xuan Zhao¹  Young Choong Kim¹  Yurngdong Jahng¹  Byeong-Seon Jeong¹  Sang-sup Jew¹ 

关键词: Asiatic acid;    Hepatoprotective effect;    Structural modification;    Hepatotoxicity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

For the development of novel hepatoprotective agents, C11, C28, C2,3,23 or C2,23,28 functional groups on asiatic acid were modified, and their hepatoprotective effects were evaluated. Most of the prepared compounds displayed potent hepatoprotective activities against CCl4- and galactosamine (GaIN)-induced hepatotoxicity. Especially, compounds 16 and 20 showed the most significant hepatoprotective effects against GaIN-induced hepatotoxicity (54.2% and 46.4% protection at 50 mM, respectively).

【 授权许可】

Unknown