A comprehensive review of cycloastragenol: Biological activity, mechanism of action and structural modifications

European Journal of Medicinal Chemistry Reports

Ke Wang¹  Haojie Che¹  Jinxin Wang¹  Mengting He¹  Huifang Wang¹  Kan Yang²  Jingchun Yao³  Guiming Zhang³ 

[1] Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, China;Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, 071002, China;Lunan Pharmaceutical Group Corporation, Linyi, Shandong, 276006, China;

关键词: Cycloastragenol;    Tetracyclic triterpene;    Biological activity;    Telomerase activator;    Mechanism of action;    Structural modification;   

DOI  :  

来源: DOAJ

【 摘 要 】

Cycloastragenol (CAG) is a sapogenin of Astragaloside IV (AG-IV), isolated from the dried roots of legumes Astragalus mongolica or Astragalus membranaceus. Cycloastragenol has a steroidal skeleton of tetracyclic triterpene and possess diverse pharmacological activities such as anti-aging, anti-inflammatory, anti-fibrosis, pro-wound healing, liver protection and endothelial protection. In addition, cycloastragenol is the only telomerase activator reported in natural products, which is closely related to MAPK and PI3K/Akt signaling pathways. This review provides a theoretical basis for the development of cycloastragenol into the candidate for the treatment of multi-factorial diseases in clinic, focusing on the extensively biological activities as well as the mechanism of action and structural modification and aiming to attract researchers to conduct in-depth studies on cycloastragenol. Meanwhile, the pharmacokinetics and toxicology studies of CAG are also described for further druggability exploration to provides valuable reference.

【 授权许可】

Unknown