The First Synthesis of Dually Modified Southern-Mimicking Nucleoside: 4'-Methyl Branched and Bicyclo [3

Bulletin of the Korean chemical society

Kwan Woo Kim¹  Joon Hee Hong¹ 

关键词: Locked-nucleoside;    [3;    3]-Sigmatropic rearrangement;    Curtius reaction;    Antiviral agents;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

This paper reports the stereoselective synthesis of a novel nucleoside, 4`-methyl branched and bicyclo [3.1.0] hexane locked-nucleoside 12, using a sequential [3,3]-sigmatropic rearrangement/carbene cycloaddition reaction/Curtius reaction strategy with a high stereoselectivity.

【 授权许可】

Unknown