Synthesis and Antiviral Evaluation of Novel Acyclic Nucleosides

Bulletin of the Korean chemical society

Joon Hee Hong¹  Ok Hyun Ko¹ 

关键词: Acyclic nucleosides;    [3;    3]-Sigmatropic rearrangement;    Antiviral agents;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A very short and concise synthetic route for a novel acyclic version of d4T is described. The required quaternary carbon was successfully installed using a [3,3]-sigmatropic rearrangement. The condensation of the mesylates 16-18 with an adenine base under standard nucleophilic substitution conditions (K2CO3, 18-Crown- 6, DMF) in addition to deblocking afforded the target acyclic nucleosides 22-24. In addition, the antiviral evaluations against various viruses were performed.

【 授权许可】

Unknown