Oxidative N-Debenzylation of N-Benzyl-N-substituted Benzylamines Catalyzed by Cytochrome P450

Bulletin of the Korean chemical society

Gang Lin¹  Ji Won Yang¹  Sung Soo Kim¹ 

关键词: Oxidations;    N-Debenzylations;    Horseradish peroxidase;    Hydrogen peroxide;    Amines;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Cytochrome P450 (P450)/O2/NADPH engender electron transfer reaction of N-benzyl-N-substituted benzylamines to yield corresponding radical cation 1 that is simultaneously converted into 2 and 3. Subsequently, expulsion of proton and hydroxylation yielding a-hydroxylamines are followed by formation of benzaldehydes and benzylamines.

【 授权许可】

Unknown