The Role of Radionuclide Imaging in Epilepsy, Part 1: Sporadic Temporal and Extratemporal Lobe Epilepsy

Journal of Nuclear Medicine

Harry T. Chugani¹  Ajay Kumar¹ 

[1] PET Center, Department of Pediatrics, Neurology, and Radiology, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan PET Center, Department of Pediatrics, Neurology, and Radiology, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan PET Center, Department of Pediatrics, Neurology, and Radiology, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan

关键词: epilepsy;    epilepsy syndromes;    ¹⁸F-FDG;    PET;    radionuclide;    epilepsy surgery;    SPECT;   

DOI  :  10.2967/jnumed.112.114397

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Epilepsy is one of the most common yet diverse neurologic disorders, affecting almost 1%–2% of the population. Presently, radionuclide imaging such as PET and SPECT is not used in the primary diagnosis or evaluation of recent-onset epilepsy. However, it can play a unique and important role in certain specific situations, such as in noninvasive presurgical localization of epileptogenic brain regions in intractable-seizure patients being considered for epilepsy surgery. Radionuclide imaging can be particularly useful if MR imaging is either negative for lesions or shows several lesions of which only 1 or 2 are suspected to be epileptogenic and if electroencephalogram changes are equivocal or discordant with the structural imaging. Similarly, PET and SPECT can also be useful for evaluating the functional integrity of the rest of the brain and may provide useful information on the possible pathogenesis of the neurocognitive and behavioral abnormalities frequently observed in these patients.

【 授权许可】

Unknown