Hyperpolarized 13C MRI and PET: In Vivo Tumor Biochemistry

Journal of Nuclear Medicine

Kevin M. Brindle¹  Sarah E. Bohndiek¹  Mikko I. Kettunen¹  David Y. Lewis¹  Ferdia A. Gallagher¹  Dmitry Soloviev¹ 

关键词: animal imaging;    molecular imaging;    MRI;    PET;   

DOI  :  10.2967/jnumed.110.085258

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Dynamic nuclear polarization (DNP) is an emerging technique for dramatically increasing the sensitivity of magnetic resonance spectroscopy (MRS). This review evaluates the potential strengths and weaknesses of DNP-enhanced 13C magnetic resonance spectroscopic imaging (DNP-MRSI) as a clinical imaging technique in comparison to PET. The major advantage of MRS is chemical shift, which enables the injected molecule to be observed separately from its metabolites, whereas the major advantage of PET is its high sensitivity. Factors such as spatial and temporal resolution and potential risks and costs of the two techniques will be discussed. PET tracers and 13C-labeled molecules that can be used in oncology will be reviewed with reference to the biologic processes they detect. Because DNP-MRSI and PET are, in principle, similar techniques for assessing tumor metabolism, the experiences gained during the development of PET may help to accelerate translation of DNP-MRSI into routine patient imaging.

【 授权许可】

Unknown