Performance Test of an LSO-APD Detector in a 7-T MRI Scanner for Simultaneous PET/MRI

Journal of Nuclear Medicine

Ciprian Catana¹  Jeffrey H. Walton¹  Martin S. Judenhofer¹  Simon R. Cherry¹  Robert E. Nutt¹  Stefan B. Siegel¹  Claus D. Claussen¹  Manfred Kneilling¹  Bernd J. Pichler¹ 

关键词: instrumentation;    molecular imaging;    PET;    animal imaging;    multimodality imaging;    PET/MRI development;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

PET combined with CT has proven to be a valuable multimodality imaging device revealing both functional and anatomic information. Although PET/CT has become completely integrated into routine clinical application and also has been used in small-animal imaging, CT provides only limited soft-tissue contrast and, in preclinical studies, exposes the animal to a relatively high radiation dose. Unlike CT, MRI provides good soft-tissue contrast even without application of contrast agents and, furthermore, does not require ionizing radiation. Methods: This project focused on combining a high-resolution PET scanner with a 7-T MRI system for animal research. Because classic PET detectors based on photomultiplier tubes cannot be used in high magnetic fields, we used a detector technology based on 10 × 10 lutetium oxyorthosilicate crystal arrays and 3 × 3 avalanche photodiode arrays. A ring of such PET detectors will ultimately be used as an insert for the 119-mm-diameter MRI bore. Results: Initial measurements with 1 PET detector module in the 7-T field during application of MRI sequences were encouraging. Position profiles from the PET detectors and a first MR image of a mouse could be acquired simultaneously. Conclusion: Further work will concentrate on the construction of a full PET detector ring with compact, integrated electronics.

【 授权许可】

Unknown