18F-FDG PET Reveals Frontotemporal Dysfunction in Children with Fever-Induced Refractory Epileptic Encephalopathy

Journal of Nuclear Medicine

Viviane Bouilleret¹  Catherine Chiron¹  Lucie Hertz-Pannier¹  Verne Caviness¹  Michel Mazzuca¹  Frederique Archambaud¹  Sebastian Rodrigo¹  Isabelle Jambaque¹  Olivier Dulac¹ 

关键词: PET;    epilepsy;    encephalopathy;    child;    cognitive impairment;   

DOI  :  10.2967/jnumed.110.077214

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Fever-induced refractory epileptic encephalopathy in school-age children (FIRES) is a recently described epileptic entity whose etiology remains unknown. Brain abnormalities shown by MRI are usually limited to mesial-temporal structures and do not account for the catastrophic neuropsychologic findings. Methods: We conducted FIRES studies in 8 patients, aged 6–13 y, using 18F-FDG PET to disclose eventual neocortical dysfunction. Voxel-based analyses of cerebral glucose metabolism were performed using statistical parametric mapping and an age-matched control group. Results: Group analysis revealed a widespread interictal hypometabolic network including the temporoparietal and orbitofrontal cortices bilaterally. The individual analyses in patients identified hypometabolic areas corresponding to the predominant electroencephalograph foci and neuropsychologic deficits involving language, behavior, and memory. Conclusion: Despite clinical heterogeneity, 18F-FDG PET reveals a common network dysfunction in patients with sequelae due to fever-induced refractory epileptic encephalopathy.

【 授权许可】

Unknown