Detection and Quantification of Large-Vessel Inflammation with 11C-(R)-PK11195 PET/CT

Journal of Nuclear Medicine

Paolo G. Camici¹  Terence Spinks¹  Frederic Lamare¹  Oliver Gaemperli¹  Rainer Hinz¹  Ornella E. Rimoldi¹  Justin C. Mason¹  Francesca Pugliese¹ 

关键词: large-vessel vasculitides;    atherosclerosis;    ¹¹C-(R)-PK11195;    positron emission tomography;    CT angiography;   

DOI  :  10.2967/jnumed.110.079038

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

We investigated whether PET/CT angiography using 11C-(R)-PK11195, a selective ligand for the translocator protein (18 kDa) expressed in activated macrophages, could allow imaging and quantification of arterial wall inflammation in patients with large-vessel vasculitis. Methods: Seven patients with systemic inflammatory disorders (3 symptomatic patients with clinical suspicion of active vasculitis and 4 asymptomatic patients) underwent PET with 11C-(R)-PK11195 and CT angiography to colocalize arterial wall uptake of 11C-(R)-PK11195. Tissue regions of interest were defined in bone marrow, lung parenchyma, wall of the ascending aorta, aortic arch, and descending aorta. Blood-derived and image-derived input functions (IFs) were generated. A reversible 1-tissue compartment with 2 kinetic rate constants and a fractional blood volume term were used to fit the time–activity curves to calculate total volume of distribution (VT). The correlation between VT and standardized uptake values was assessed. Results: VT was significantly higher in symptomatic than in asymptomatic patients using both image-derived total plasma IF (0.55 ± 0.15 vs. 0.27 ± 0.12, P = 0.009) and image-derived parent plasma IF (1.40 ± 0.50 vs. 0.58 ± 0.25, P = 0.018). A good correlation was observed between VT and standardized uptake value (R = 0.79; P = 0.03). Conclusion: 11C-(R)-PK11195 imaging allows visualization of macrophage infiltration in inflamed arterial walls. Tracer uptake can be quantified with image-derived IF without the need for metabolite corrections and evaluated semiquantitatively with standardized uptake values.

【 授权许可】

Unknown