Human Biodistribution and Dosimetry of the D2/3 Agonist 11C-N-Propylnorapomorphine (11C-NPA) Determined from PET

Journal of Nuclear Medicine

N. Scott Mason¹  Rajesh Narendran¹  Charles M. Laymon¹  W. Gordon Frankle¹  Maralee Y. Litschge¹  Chester A. Mathis¹  Jonathan P. Carney¹  Brian J. Lopresti¹  James M. Mountz¹ 

关键词: molecular imaging;    PET;    radiobiology/dosimetry;    dopamine;    neuroreceptor;   

DOI  :  10.2967/jnumed.108.058131

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

We measured the whole-body distribution of intravenously injected 11C-N-propylnorapomorphine (11C-NPA), a dopamine agonist PET tracer, in human subjects and determined the resulting absorbed radiation doses. Methods: Six subjects (3 women, 3 men) were injected with 11C-NPA (nominal dose, 370 MBq). A total of 9 consecutive whole-body PET scans were obtained for each subject. In addition, time–activity curves for 12 organs were determined, and residence times were computed for each subject. Dosimetry was determined for the various body organs and the whole body. Results: The average NPA whole-body radiation dose was 3.17 × 10−3 mSv per MBq of injected 11C-NPA. The organ receiving the highest dose was the gallbladder wall, with an average of 2.81 × 10−2 mSv·MBq−1. Conclusion: On the basis of averaged dosimetry results, an administration of less than 1,780 MBq (<48 mCi) of 11C-NPA yields an organ dose of under 50 mSv (5 rem) to all organs.

【 授权许可】

Unknown