Clinical Utility of 18F-FDG PET for Patients with Salivary Gland Malignancies

Journal of Nuclear Medicine

Sang Yoon Kim¹  Jae Seung Kim¹  Kyung-Ja Cho¹  Chang Hwan Ryu¹  Jeong Hyun Lee¹  Seung-Ho Choi¹  Jong-Lyel Roh¹  Soon Yuhl Nam¹ 

关键词: salivary gland cancer;    ¹⁸F-FDG PET;    staging;    histologic grading;    predictive factor;    standardized uptake value;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The clinical utility of 18F-FDG PET in evaluating salivary gland malignancies has not been well defined. We therefore evaluated the utility of 18F-FDG PET in management for patients with salivary gland cancers. Methods: Thirty-four patients with newly diagnosed salivary gland cancers underwent CT and 18F-FDG PET before surgical resection with radiotherapy. The diagnostic accuracies of CT and 18F-FDG PET for detecting primary tumors and neck metastases were compared with a histopathologic reference. We determined the relationship between the maximum standardized uptake value (SUV) of the tumor and clinicopathologic parameters such as sex, age, local tumor invasion, T and N categories, TNM stage, and histologic grade, as well as their associations with disease-free survival (DFS). Results: 18F-FDG PET was more sensitive than CT for the detection of primary tumors (91.2% vs. 79.4%; P < 0.05), cervical metastases (80.5% vs. 56.1%; P < 0.05), and distant metastases in 2 patients at initial staging. High-grade malignancies had higher mean maximum SUVs than did low- and intermediate-grade malignancies (4.6 vs. 2.8; P = 0.011). T and N categories were independent determinants of DFS (P < 0.05), but the maximum SUV (4.0) was not. During a mean follow-up of 25.1 mo, 18F-FDG PET correctly diagnosed local–regional recurrences in 6 patients and new distant metastases in 9 patients. Conclusion: Our findings indicate that, in patients with salivary gland malignancies, 18F-FDG PET is clinically useful in initial staging, histologic grading, and monitoring after treatment but not in predicting patient survival.

【 授权许可】

Unknown