Kinetic Analysis of 18F-Fluorodihydrorotenone as a Deposited Myocardial Flow Tracer: Comparison to 201Tl

Journal of Nuclear Medicine

Michael La Belle¹  Robert C. Marshall¹  Henry F. VanBrocklin¹  Patricia Powers-Risius¹  Bryan W. Reutter¹  Ronald H. Huesman¹  James P. O’Neil¹ 

[1] Department of Nuclear Medicine and Functional Imaging, E.O. Lawrence Berkeley National Laboratory, University of California, Berkeley, California Department of Nuclear Medicine and Functional Imaging, E.O. Lawrence Berkeley National Laboratory, University of California, Berkeley, California Department of Nuclear Medicine and Functional Imaging, E.O. Lawrence Berkeley National Laboratory, University of California, Berkeley, California

关键词: myocardial perfusion;    ¹⁸F-fluorodihydrorotenone;    PET;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The goals of this investigation were to assess the accuracy of 18F-fluorodihydrorotenone (18F-FDHR) as a new deposited myocardial flow tracer and to compare the results to those for 201Tl. Methods: The kinetics of these flow tracers in 22 isolated, erythrocyte- and albumin-perfused rabbit hearts were evaluated over a flow range encountered in patients. The 2 flow tracers plus a vascular reference tracer (131I-albumin) were introduced as a bolus through a port just above the aortic cannula. Myocardial extraction, retention, washout, and uptake parameters were computed from the venous outflow curves with the multiple-indicator dilution technique and spectral analysis. Results: The mean ± SD initial extraction fractions for 18F-FDHR (0.85 ± 0.07) and 201Tl (0.87 ± 0.05) were not significantly different, although the initial extraction fraction for 18F-FDHR declined with flow (P < 0.0001), whereas the initial extraction fraction for 201Tl did not. The washout of 201Tl was faster (P < 0.001) and more affected by flow (P < 0.05) than was the washout of 18F-FDHR. Except for the initial extraction fraction, 18F-FDHR retention was higher (P < 0.001) and less affected by flow (P < 0.05) than was 201Tl retention. Reflecting its superior retention, the net uptake of 18F-FDHR was better correlated with flow than was that of 201Tl at both 1 and 15 min after tracer introduction (P < 0.0001 for both comparisons). Conclusion: The superior correlation of 18F-FDHR uptake with flow indicates that it is a better flow tracer than 201Tl in the isolated rabbit heart. Compared with the other currently available positron-emitting flow tracers (82Rb, 13N-ammonia, and 15O-water), 18F-FDHR has the potential of providing excellent image resolution without the need for an on-site cyclotron.

【 授权许可】

Unknown