Loss of Dopamine Transporter Binding in Parkinson’s Disease Follows a Single Exponential Rather Than Linear Decline

Journal of Nuclear Medicine

Oliver Pogarell¹  Walter Koch¹  Alexander Storch¹  Klaus Tatsch¹  Perry E. Radau¹  Johannes Schwarz¹ 

关键词: Parkinson’s disease;    dopamine transporter;    SPECT;    rate of decline;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Imaging of l-dopa uptake or dopamine transporter binding can monitor the progression of Parkinson’s disease. Most follow-up studies have provided data best fitted by a linear decline of their outcome measure. However, in these studies, patients were repeatedly scanned during their first years after a diagnosis had been established. Methods: We followed 6 patients with early Parkinson’s disease for 7.5 y using 123I-labeled N-(3-iodopropene-2-yl)-2β-carbomethoxy-3β-(4-chlorophenyl) tropane and SPECT. Results: Loss of dopamine transporter binding was best fitted using a single exponential approximation. A 63% loss (τ [time constant tau]) was calculated as 5.18 ± 7.62 y in the putamen and 10.62 ± 31.4 y in the caudate nucleus when a 3-parameter fit was used. Conclusion: These data approximate, for what is to our knowledge the first time, the decline of dopamine transporter binding as expected in biologic systems and may allow for models that correct for exponential decline to be developed and for disease-modifying effects in patients with advanced disease to be determined.

【 授权许可】

Unknown