Incremental Diagnostic Value of Preoperative 99mTc-MIBI SPECT in Patients with a Parathyroid Adenoma

Journal of Nuclear Medicine

Sorina Macadziob¹  Pinhas Schachter¹  Irit Minski¹  Galina Nikolov¹  Mordechai Lorberboym¹ 

关键词: parathyroid;    adenoma;    ^99mTc-methoxyisobutylisonitrile;    SPECT;    radioguided surgery;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The purpose of this prospective study was to evaluate the diagnostic value of early parathyroid SPECT combined with quantitative analysis as compared with planar imaging in patients undergoing minimally invasive radioguided surgery. Methods: A total of 52 consecutive patients with primary hyperparathyroidism underwent planar and SPECT parathyroid scintigraphy 2–5 d before surgery. Each patient had a single-tracer dual-phase technique using 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) and a double-tracer subtraction technique using a delayed 99mTc-pertechnetate scan. Immediately after the first 99mTc-MIBI planar image, a SPECT study was acquired. Before radioguided parathyroidectomy, each patient was reinjected with 99mTc-MIBI. Serum calcium levels were available for all patents before surgery and at 8 and 24 h after surgery. Serum parathyroid hormone (PTH) levels were also available for all patients. Quantitative analysis was performed using the average count ratio of parathyroid to left thyroid lobe, right thyroid lobe, and maximum thyroid activity. All patients had histopathologic examination of the removed glands. Results: The average time for radioguided surgery was 30 min (range, 20–40 min). Postsurgical calcium levels correlated significantly with the adenoma weight (r = 0.5; P = 0.016). Combined planar scintigraphy correctly identified 41 adenomas (79%). SPECT increased the sensitivity to 96%. SPECT was superior to planar imaging in 9 patients, mainly in patients with ectopic adenomas or with multinodular goiters. Gland size did not affect significantly the detectability of SPECT. 99mTc-MIBI retention was noted in only 31 adenomas (60%). The average uptake ratios of parathyroid counts to the left lobe, right lobe, and maximum thyroid activity were 1.20 ± 0.42, 1.29 ± 0.45, and 0.84 ± 0.35, respectively. The latter ratio was significantly correlated with PTH levels before surgery (r = 0.408; P = 0.04). Conclusion: Our data indicate that early preoperative SPECT in patients with primary hyperparathyroidism is essential for accurate localization of parathyroid adenomas and for the selection of patients who are candidates for minimally invasive radioguided surgery. Planar parathyroid imaging is less sensitive compared with SPECT, and washout kinetics of 99mTc-MIBI are unreliable in the dual-phase technique. Patients with higher presurgical PTH levels may especially benefit from radioguided surgery.

【 授权许可】

Unknown