Cardiovascular proteomics in the era of big data: experimental and computational advances

Clinical Proteomics

Ding Wang¹  Dominic C. M. Ng¹  Edward Lau¹  Peipei Ping²  Maggie P. Y. Lam¹ 

[1] NIH BD2K Center of Excellence at UCLA; Department of Physiology, University of California at Los Angeles, Los Angeles, USANIH BD2K Center of Excellence at UCLA; Department of Physiology, University of California at Los Angeles, Los Angeles, USANIH BD2K Center of Excellence at UCLA; Department of Physiology, University of California at Los Angeles, Los Angeles, USA;NIH BD2K Center of Excellence at UCLA; Department of Physiology, University of California at Los Angeles, Los Angeles, USADepartment of Medicine, University of California at Los Angeles, Los Angeles, USADepartment of Bioinformatics, University of California at Los Angeles, Los Angeles, USANIH BD2K Center of Excellence at UCLA; Department of Physiology, University of California at Los Angeles, Los Angeles, USANIH BD2K Center of Excellence at UCLA; Department of Physiology, University of California at Los Angeles, Los Angeles, USADepartment of Medicine, University of California at Los Angeles, Los Angeles, USADepartment of Bioinformatics, University of California at Los Angeles, Los Angeles, USADepartment of Medicine, University of California at Los Angeles, Los Angeles, USANIH BD2K Center of Excellence at UCLA; Department of Physiology, University of California at Los Angeles, Los Angeles, USADepartment of Medicine, University of California at Los Angeles, Los Angeles, USADepartment of Bioinformatics, University of California at Los Angeles, Los Angeles, USADepartment of Bioinformatics, University of California at Los Angeles, Los Angeles, USANIH BD2K Center of Excellence at UCLA; Department of Physiology, University of California at Los Angeles, Los Angeles, USADepartment of Medicine, University of California at Los Angeles, Los Angeles, USADepartment of Bioinformatics, University of California at Los Angeles, Los Angeles, USA

关键词: Cardiovascular medicine;    Clinical proteomics;    Shotgun proteomics;    Mass spectrometry;   

DOI  :  10.1186/s12014-016-9124-y

来源: Humana Press Inc

【 摘 要 】

Abstract

Proteomics plays an increasingly important role in our quest to understand cardiovascular biology. Fueled by analytical and computational advances in the past decade, proteomics applications can now go beyond merely inventorying protein species, and address sophisticated questions on cardiac physiology. The advent of massive mass spectrometry datasets has in turn led to increasing intersection between proteomics and big data science. Here we review new frontiers in technological developments and their applications to cardiovascular medicine. The impact of big data science on cardiovascular proteomics investigations and translation to medicine is highlighted.

【 授权许可】

Unknown