Association of Alpha B-Crystallin (CRYAB) Genotypes with Breast Cancer Susceptibility in Taiwan

Cancer Genomics - Proteomics

Chien-Yi Ho⁵  Chih-Hsueh Lin⁶  Liang-Chih Liu³  Da-Tian Bau⁴  Wen-Shin Chang⁶  Hsien-Yuan Lane¹  Hwei-Chung Wang³  Chao-I Wu⁵  Yi-Hsien Hsieh²  Chen-Hsien Su³  Chia-Wen Tsai⁶ 

[1] Clinical Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Clinical Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Clinical Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.;Department of Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Department of Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.Department of Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Department of Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.;Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Institution of Basic Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Clinical Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Institution of Basic Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Clinical Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Institution of Basic Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Institution of Basic Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Clinical Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Clinical Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Institution of Basic Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Clinical Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.;Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Institution of Basic Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Institution of Basic Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Institution of Basic Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.Institution of Basic Medical Sciences, China Medical University, Taichung, Taiwan, R.O.C.

关键词: Alpha B-crystallin;    polymorphism;    breast cancer;    carcinogenesis;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Aim: Alpha B-Crystallin (CRYAB) is purported to be a metastasis suppressor protein, and lack or lower CRYAB expression is a prognostic biomarker for several types of cancer, such as that of the prostate and head and neck. However, the association of genomic variation of CRYAB and breast cancer is not well studied. The aim of this study was to evaluate the association of polymorphic genotypes of CRYAB with breast cancer within a Taiwanese population. Patients and Methods: In this hospital-based study, 1232 patients with breast cancer and an equal number of healthy controls in central Taiwan were genotyped via polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) and the association of CRYAB A-1215G (rs2228387), C-802G (rs14133) and intron 2 (rs2070894) polymorphisms with breast cancer risk in a central Taiwanese population was investigated. Results: Those individuals with CRYAB C-802G CG and GG genotypes had 1.50- and 2.22-fold risk for breast cancer than those with the CC genotype. As for the A-1215G and intron 2 polymorphisms, there was no significant association of the genotype with breast cancer risk. In allelic frequency analysis, the G allele CRYAB C-802G conferred a significantly (p=5.63×10–10) increased risk of breast cancer. Our results provide evidence that the G allele of CRYAB C-802G is correlated with breast cancer risk and this polymorphism may be a useful marker for early detection of breast cancer in clinical practice.

【 授权许可】

Unknown