PGF Isoforms, PLGF-1 and PGF-2, in Colorectal Cancer and the Prognostic Significance

Cancer Genomics - Proteomics

ASTRID ESCUDERO-ESPARZA¹  WEN G. JIANG¹  MANSEL LEIGH DAVIES¹  TRACEY A. MARTIN¹ 

[1] Metastasis and Angiogenesis Research Group, University Department of Surgery, Cardiff School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom Metastasis and Angiogenesis Research Group, University Department of Surgery, Cardiff School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom Metastasis and Angiogenesis Research Group, University Department of Surgery, Cardiff School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom

关键词: Colorectal cancer;    immunohistochemistry;    placenta growth factor;    prognosis;    real-time quantitative polymerase chain reaction;    vascular endothelial growth factor;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Aim: This study examined the expression of PLGF-1 and PGF-2 in human colorectal cancer and how changes in expression may be linked to prognosis of the disease. Materials and Methods: Expression of PLGF transcripts in primary colorectal tumours (n=94) and background tissue (n=80) were analysed by Q-PCR. Immunohistochemistry was carried out on a number of matched background and tumour sections. Results: There was a progressive increase in Dukes A to C (430±134 versus 674±2680) and with TNM 1 to 3 as compared to background tissues (479±152 versus 777±327 p=0.032). Interestingly, there was an increase in PLGF-1 expression in patients with poor outcome compared with patients remaining disease-free. PGF-2 expression was significantly elevated in tumours compared to normal (4558±240 versus 859±67.3 p<0.0001). Moreover, expression was increased in patients with poor prognosis compared to those remaining disease free (4585±285 versus 3909±446). Conclusion: There is increased expression of the PLGF isoforms in human colorectal cancer.

【 授权许可】

Unknown