Immune regulation of Rab proteins expression and intracellular transport

Journal of Leukocyte Biology

Gang Pei¹  Maximiliano Gabriel Gutierrez¹  Marc Bronietzki¹ 

[1] Research Group Phagosome Biology, Helmholtz Centre for Infection Research, Braunschweig, GermanyResearch Group Phagosome Biology, Helmholtz Centre for Infection Research, Braunschweig, GermanyResearch Group Phagosome Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

关键词: macrophages;    phagosomes;    mycobacteria;    interleukins;   

DOI  :  10.1189/jlb.0212076

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Compartmentalization in cells of the immune system, the focus of this review, facilitates the spatiotemporal organization of cellular responses essential for specialized immune functions. In this process of compartment maintenance, Rab proteins are central regulators of protein-mediated transport and fusion of intracellular structures. It is widely believed that the intracellular concentration of proteins that regulate intracellular transport, including Rab proteins, is constitutively mantained. However, there is a growing body of evidence indicating that transcriptional rates of Rab proteins can be modified. This process is especially evident during immune activation and argues that after activation, these cells require higher levels of Rab proteins. The aim of this review is to discuss evidence showing the increasing links between Rab protein expression and intracellular transport, particularly in monocytes and macrophages. We highlight here biological processes in which the expression of Rab GTPases is selectively regulated, leading to the activation of specific intracellular routes. Further, we focus on the immune regulation of intracellular transport after cytokine activation and microbial infection, with an emphasis in mycobacterial infection.

【 授权许可】

Unknown