Immune regulation of Rab proteins expression and intracellular transport

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: macrophages;    phagosomes;    mycobacteria;    interleukins;   

DOI  :  10.1189/jlb.0212076

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Compartmentalizationincellsoftheimmunesystem,thefocusofthisreview,facilitatesthespatiotemporalorganizationofcellularresponsesessentialforspecializedimmunefunctions.Inthisprocessofcompartmentmaintenance,Rabproteinsarecentralregulatorsofprotein‐mediatedtransportandfusionofintracellularstructures.Itiswidelybelievedthattheintracellularconcentrationofproteinsthatregulateintracellulartransport,includingRabproteins,isconstitutivelymantained.However,thereisagrowingbodyofevidenceindicatingthattranscriptionalratesofRabproteinscanbemodified.Thisprocessisespeciallyevidentduringimmuneactivationandarguesthatafteractivation,thesecellsrequirehigherlevelsofRabproteins.TheaimofthisreviewistodiscussevidenceshowingtheincreasinglinksbetweenRabproteinexpressionandintracellulartransport,particularlyinmonocytesandmacrophages.WehighlightherebiologicalprocessesinwhichtheexpressionofRabGTPasesisselectivelyregulated,leadingtotheactivationofspecificintracellularroutes.Further,wefocusontheimmuneregulationofintracellulartransportaftercytokineactivationandmicrobialinfection,withanemphasisinmycobacterialinfection...

【 授权许可】

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