The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond

Journal of Leukocyte Biology

Florence Roan²  Thomas A. Stoklasek²  Bryan D. Bell²  *²  Steven F. Ziegler²  Masayuki Kitajima, ¹  Hongwei Han²  Bryan D. Bell, ¹  Thomas A. Stoklasek, ¹  Hongwei Han, , and¹  Masayuki Kitajima²  Florence Roan, ³  Steven F. Ziegler, ¹ 

[1] Immunology Program, Benaroya Research Institute, Seattle, Washington, USA; and  Department of Immunology;Immunology Program, Benaroya Research Institute, Seattle, Washington, USA; and Department of Immunology and Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA Immunology Program, Benaroya Research Institute, Seattle, Washington, USA; and Immunology Program, Benaroya Research Institute, Seattle, Washington, USA; and Department of Immunology and Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA Department of Immunology and Immunology Program, Benaroya Research Institute, Seattle, Washington, USA; and Department of Immunology and Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA Immunology Program, Benaroya Research Institute, Seattle, Washington, USA; and Department of Immunology and Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA;Immunology Program, Benaroya Research Institute, Seattle, Washington, USA; and  Department of Immunology and Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA

关键词: atopic;    cancer;    autoimmunity;    skin;    lung;    intestines;   

DOI  :  10.1189/jlb.1211622

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Originally shown to promote the growth and activation of B cells, TSLP is now known to have wide-ranging impacts on hematopoietic and nonhematopoietic cell lineages, including DCs, basophils, eosinophils, mast cells, CD4+, CD8+, and NK T cells, B cells, and epithelial cells. Whereas the role of TSLP in the promotion of TH2 responses has been studied extensively in the context of lung- and skin-specific allergic disorders, it is becoming increasingly clear that TSLP may impact multiple disease states within multiple organ systems, including the blockade of TH1/TH17 responses and the promotion of cancer and autoimmunity. This review will highlight recent advances in the understanding of TSLP signal transduction, as well as the role of TSLP in allergy, autoimmunity, and cancer. Importantly, these insights into the multifaceted roles of TSLP could potentially allow for novel, therapeutic manipulations of these disorders.

【 授权许可】

Unknown