Regulation of angiostatic chemokines driven by IL-12 and IL-27 in human tumors

Journal of Leukocyte Biology

Domenico Ribatti ²  Domenico Ribatti³  *³  Irma Airoldi³  Irma Airoldi and¹ 

[1] AIRC Tumor Immunology Unit, Department of Experimental and Laboratory Medicine, G. Gaslini Institute, Genova, Italy; Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy AIRC Tumor Immunology Unit, Department of Experimental and Laboratory Medicine, G. Gaslini Institute, Genova, Italy;;AIRC Tumor Immunology Unit, Department of Experimental and Laboratory Medicine, G. Gaslini Institute, Genova, Italy; and Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy AIRC Tumor Immunology Unit, Department of Experimental and Laboratory Medicine, G. Gaslini Institute, Genova, Italy; and AIRC Tumor Immunology Unit, Department of Experimental and Laboratory Medicine, G. Gaslini Institute, Genova, Italy; and Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy AIRC Tumor Immunology Unit, Department of Experimental and Laboratory Medicine, G. Gaslini Institute, Genova, Italy; and Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy

关键词: angiogenesis;    antiangiogenesis;    multiple myeloma;    non small cell lung carcinoma;   

DOI  :  10.1189/jlb.0511237

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Chemokines have pleiotropic effects in regulating immunity, angiogenesis, and tumor growth. CXC and CC chemokine families members and their receptors are able to exert a proangiogenic or an antiangiogenic effect in experimental models and in human tumors. In this review article, we have summarized literature data and our studies concerning the angiostatic activity of chemokines. Their angiostatic activity may be a result of a direct effect on the biological functions of endothelial cells and/or an effect on tumor cells inhibiting their capability to stimulate new blood vessel formation. Moreover, chemokines have a pro- and antitumor effect within the tumor microenvironment by regulating immune cell infiltration and its antitumor activities. We have focused our interest on the role of IL-12 and IL-27 in solid and hematological tumors, and we have suggested and discussed their potential use as antiangiogenic agents in the treatment of such tumors.

【 授权许可】

Unknown