| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Regulation of angiostatic chemokines driven by IL‐12 and IL‐27 in human tumors | |
| 关键词: angiogenesis; antiangiogenesis; multiple myeloma; non small cell lung carcinoma; | |
| DOI : 10.1189/jlb.0511237 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Chemokineshavepleiotropiceffectsinregulatingimmunity,angiogenesis,andtumorgrowth.CXCandCCchemokinefamiliesmembersandtheirreceptorsareabletoexertaproangiogenicoranantiangiogeniceffectinexperimentalmodelsandinhumantumors.Inthisreviewarticle,wehavesummarizedliteraturedataandourstudiesconcerningtheangiostaticactivityofchemokines.Theirangiostaticactivitymaybearesultofadirecteffectonthebiologicalfunctionsofendothelialcellsand/oraneffectontumorcellsinhibitingtheircapabilitytostimulatenewbloodvesselformation.Moreover,chemokineshaveapro‐andantitumoreffectwithinthetumormicroenvironmentbyregulatingimmunecellinfiltrationanditsantitumoractivities.WehavefocusedourinterestontheroleofIL‐12andIL‐27insolidandhematologicaltumors,andwehavesuggestedanddiscussedtheirpotentialuseasantiangiogenicagentsinthetreatmentofsuchtumors...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904042061691ZK.pdf | 863KB |  download |
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