The macrophage: the intersection between HIV infection and atherosclerosis

Journal of Leukocyte Biology

Anthony Jaworowski³  Nigora Mukhamedova⁵  Suzanne M. Crowe⁴  Michael Bukrinsky¹  Clare L. V. Westhorpe²  Dmitri Sviridov⁵ 

[1] The George Washington University Medical Center, Washington, DC, USA The George Washington University Medical Center, Washington, DC, USA The George Washington University Medical Center, Washington, DC, USACentre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia;Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Medicine and Immunology, Monash University, Melbourne, Australia; Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Medicine and Immunology, Monash University, Melbourne, Australia; Medicine and Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Medicine and Immunology, Monash University, Melbourne, Australia; Immunology, Monash University, Melbourne, Australia; Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Medicine and Immunology, Monash University, Melbourne, Australia;;Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Infectious Diseases Unit, The Alfred Hospital, Melbourne, Australia; Departments of Medicine and Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Infectious Diseases Unit, The Alfred Hospital, Melbourne, Australia; Departments of Medicine and Infectious Diseases Unit, The Alfred Hospital, Melbourne, Australia; Departments of Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Infectious Diseases Unit, The Alfred Hospital, Melbourne, Australia; Departments of Medicine and Medicine and Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Infectious Diseases Unit, The Alfred Hospital, Melbourne, Australia; Departments of Medicine and;Baker IDI Heart and Diabetes Institute, Melbourne, Australia; and Baker IDI Heart and Diabetes Institute, Melbourne, Australia; and Baker IDI Heart and Diabetes Institute, Melbourne, Australia; and

关键词: inflammation;    monocyte migration;    cholesterol;    coronary heart disease;   

DOI  :  10.1189/jlb.0809580

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

HIV-infected individuals are at increased risk of coronary artery disease (CAD) with underlying mechanisms including chronic immune activation and inflammation secondary to HIV-induced microbial translocation and low-grade endotoxemia; direct effects of HIV and viral proteins on macrophage cholesterol metabolism; and dyslipidemia related to HIV infection and specific antiretroviral therapies. Monocytes are the precursors of the lipid-laden foam cells within the atherosclerotic plaque and produce high levels of proinflammatory cytokines such as IL-6. The minor CD14+/CD16+ “proinflammatory” monocyte subpopulation is preferentially susceptible to HIV infection and may play a critical role in the pathogenesis of HIV-related CAD. In this review, the central role of monocytes/macrophages in HIV-related CAD and the importance of inflammation and cholesterol metabolism are discussed.

【 授权许可】

Unknown