| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| The macrophage: the intersection between HIV infection and atherosclerosis | |
| 关键词: inflammation; monocyte migration; cholesterol; coronary heart disease; | |
| DOI : 10.1189/jlb.0809580 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
HIV‐infectedindividualsareatincreasedriskofcoronaryarterydisease(CAD)withunderlyingmechanismsincludingchronicimmuneactivationandinflammationsecondarytoHIV‐inducedmicrobialtranslocationandlow‐gradeendotoxemia;directeffectsofHIVandviralproteinsonmacrophagecholesterolmetabolism;anddyslipidemiarelatedtoHIVinfectionandspecificantiretroviraltherapies.Monocytesaretheprecursorsofthelipid‐ladenfoamcellswithintheatheroscleroticplaqueandproducehighlevelsofproinflammatorycytokinessuchasIL‐6.TheminorCD14+/CD16+“proinflammatory”monocytesubpopulationispreferentiallysusceptibletoHIVinfectionandmayplayacriticalroleinthepathogenesisofHIV‐relatedCAD.Inthisreview,thecentralroleofmonocytes/macrophagesinHIV‐relatedCADandtheimportanceofinflammationandcholesterolmetabolismarediscussed...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904040763831ZK.pdf | 256KB |  download |
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