The generation of T cell memory: a review describing the molecular and cellular events following OX40 (CD134) engagement

Journal of Leukocyte Biology

Rodney A. Prell¹  Colin Thalhofer²  Tom Shi²  Dean E. Evans²  Andrew D. Weinberg² 

[1] Cell Genesys, Foster City, California Cell Genesys, Foster City, California Cell Genesys, Foster City, California;Earle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Medical Center, Oregon; and Earle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Medical Center, Oregon; and Earle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Medical Center, Oregon; and

关键词: TNF-R;    antigen-specific T cells;    autoimmunity;    tumor immunology;   

DOI  :  10.1189/jlb.1103586

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

OX40 (CD134), a membrane-bound member of the tumor necrosis factor-receptor superfamily, is expressed primarily on activated CD4+ T cells. Following engagement on the cell surface, OX40 delivers a costimulatory signal that leads to potent, proinflammatory effects. Engagement of OX40 during antigen (Ag)-specific stimulation of T cells leads to increased production of memory T cells, increased migration of Ag-specific T cells, enhanced cytokine production by effector T cells, and the ability to break peripheral T cell tolerance in vivo. Therefore, OX40 engagement in vivo could have important ramifications for the enhancement of vaccine strategies and inhibition of unwanted inflammation. This review summarizes the molecular and cellular events that occur following OX40 engagement during Ag-specific T cell activation.

【 授权许可】

Unknown