No requirement of reactive oxygen intermediates in Fas‐mediated apoptosis

FEBS Letters

Enari, Masato¹  Hug, Hubert¹  Nagata, Shigekazu¹ 

[1] Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565, Japan

关键词: Apoptosis;    Fas;    Signal transduction;    Reactive oxygen intermediate;    ROI;    reactive oxygen intermediates;    TNF;    tumor necrosis factor;    TNF-R;    tumor necrosis factor receptor;    DEM;    diethylmaleate;    HO•;    hydroxyl radical;    H2O2;    hydrogen peroxide;    GSH;    glutathione;    GSH-OET;    l-γ-glutamyl-l-cysteinylglycyl-O-ethyl ester;    γ-GluCys;    l-γ-glutamyl-l-cysteine;   

DOI  :  10.1016/0014-5793(94)00852-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Fas is a cell surface molecule that mediates apoptosis, but the intracellular mechanisms leading to apoptosis are not well understood. It is known that diethylmaleate (DEM)-induced cell death can be blocked by substances with antioxidant activity. Here we have studied whether antioxidants have any effect on Fas-mediated apoptosis and show that they are not able to block Fas-mediated apoptosis. Therefore, it seems that reactive oxygen intermediate (ROI)-dependent and -independent mechanisms which lead to apoptosis do exist. Fas-mediated apoptosis probably proceeds via a ROI-independent pathway.

【 授权许可】

Unknown