Collectins and their role in lung immunity

Journal of Leukocyte Biology

H. Clark³  R. B. Sim³  R. Malhotra²  T. P. Hickling¹ 

[1] MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom; Virus Research Group, Institute of Infection Immunity and Inflammation, School of Clinical Laboratory Sciences, Queen’s Medical Centre, University of Nottingham, United Kingdom; and MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom; MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom; Virus Research Group, Institute of Infection Immunity and Inflammation, School of Clinical Laboratory Sciences, Queen’s Medical Centre, University of Nottingham, United Kingdom; and Virus Research Group, Institute of Infection Immunity and Inflammation, School of Clinical Laboratory Sciences, Queen’s Medical Centre, University of Nottingham, United Kingdom; and MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom; Virus Research Group, Institute of Infection Immunity and Inflammation, School of Clinical Laboratory Sciences, Queen’s Medical Centre, University of Nottingham, United Kingdom; and;MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, United Kingdom MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom; MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, United Kingdom GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, United Kingdom MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, United KingdomMRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom; MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom; MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom;

关键词: surfactant proteins A and D;    mannan-binding lectin;    C-type lectin;    collagenous regions;   

DOI  :  10.1189/jlb.0703304

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

The collectins are a small family of secreted glycoproteins that contain C-type lectin domains and collagenous regions. They have an important function in innate immunity, recognizing and binding to microorganisms via sugar arrays on the microbial surface. Their function is to enhance adhesion and phagocytosis of microorganisms by agglutination and opsonization. In the lung, two members of the collectin family, surfactant proteins A and D, are major protein constituents of surfactant. Another collectin, mannan-binding lectin, is also present in the upper airways and buccal cavity and may protect against respiratory infections. Recent work has shown that collectins have roles in resistance to allergy and in the control of apoptosis and clearance of apoptotic macrophage in the lung.

【 授权许可】

Unknown