Anti-Influenza A Virus Activities of Mannan-Binding Lectins and Bovine Conglutinin

Journal of Veterinary Medical Science

Katsuki OHTANI³  Takashi SAKAMOTO¹  Tetsuo KASE⁴  Yasuhiko SUZUKI²  Takao KAWAI⁴  Souji EDA¹  Nobutaka WAKAMIYA³ 

[1] Department of Biological Science Research, Research & Development Center, Fuso Pharmaceutical Industries, Ltd.;Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control;Department of Microbiology and Immunochemistry, Asahikawa Medical College;Department of Infectious Diseases, Osaka Prefectural Institute of Public Health

关键词: conglutinin;    influenza A virus;    mannan-binding lectin;   

DOI  :  10.1292/jvms.69.221

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(31)Cited-By(6)Mannan-binding lectin (MBL) and bovine conglutinin (BKg) belong to the collectin family, which is involved in first-line host defense against various infectious agents. We have previously reported that human MBL inhibited type A influenza viral hemagglutination, infection and spreading to adjacent cells without complement activation. In this study, we investigated the direct antiviral activities of bovine MBL, rabbit MBL and BKg. All collectins used in this study inhibited viral infectivity and hemagglutination at concentrations of 0.02-0.3 μg/ml. They also demonstrated inhibitory activity against viral spreading. Like human MBL, bovine MBL and BKg showed antiviral activities at their physiological concentrations. These results suggest that mammalian MBLs and BKg may inhibit the spread of influenza A virus through the bloodstream.

【 授权许可】

Unknown