期刊论文详细信息
Journal of Leukocyte Biology
Sepsis-induced SOCS-3 expression is immunologically restricted to phagocytes
Y. Chen1  A. Ayala1  C. S. Chung1  P. S. Grutkoski1 
[1] Division of Surgical Research, Rhode Island Hospital and Brown University Medical School, ProvidenceDivision of Surgical Research, Rhode Island Hospital and Brown University Medical School, ProvidenceDivision of Surgical Research, Rhode Island Hospital and Brown University Medical School, Providence
关键词: macrophage;    neutrophil;    immunosuppression;    CLP;    mouse;   
DOI  :  10.1189/jlb.0303108
学科分类:生理学
来源: Federation of American Societies for Experimental Biology
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【 摘 要 】

We have shown that immune cells from septic mice exhibit a suppressed response to exogenous stimuli in vitro. The suppressors of the cytokine signaling (SOCS) family are proteins that block intracellular signaling and can be induced by inflammatory mediators. Therefore, we hypothesized that SOCS-3 is up-regulated in immune cells in response to a septic challenge induced by cecal ligation and puncture (CLP). Mice were subjected to CLP or sham-CLP, and 2–48 h later, the blood, thymus, spleen, lung, and peritoneal leukocytes were harvested and examined. SOCS-3 was undetectable in thymocytes or blood leukocytes. In contrast, SOCS-3 was up-regulated in the spleen, lung, and peritoneal leukocytes in a time-dependent manner. Further examination revealed that only the macrophages and neutrophils expressed SOCS-3. These data suggest that cytokines and bacterial toxins present during sepsis have the ability to suppress the cytokine and/or lipopolysaccharide response and the function of immune cells by up-regulating SOCS-3.

【 授权许可】

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