Measurement of 18F-FDG Concentrations in Blood Samples: Comparison of Direct Calibration and Standard Solution Methods

Journal of Nuclear Medicine Technology

Arthur van Lingen¹  Henri N.J.M. Greuter¹  Eric J.F. Franssen¹  Ronald Boellaard¹  Adriaan A. Lammertsma¹ 

关键词: blood samples;    activity concentration;    ¹⁸F-FDG;    dose calibrator;    well counter;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Objective: The purpose of this study was to compare the accuracy and reliability of 2 well counter methods for measuring the activity concentration of 18F-FDG in blood samples.Methods: Three to 5 blood samples from 154 patient studies were weighed and measured in a well counter. The 18F-FDG activity concentration was derived using, first, a direct calibration factor to convert measured well counter readings into activity concentration and, second, a comparison of measured counts with those of a specified standard solution.Results: The ratio between the activity concentration results of the 2 methods was 0.996 ± 0.033, indicating that the methods provided equal results.Conclusion: Because the standard solution method is more prone to human error, less reproducible, and more labor intensive, preference should be given to the direct calibration method.

【 授权许可】

Unknown