Accurate Dose Calibrator Activity Measurement of 90Y-Ibritumomab Tiuxetan

Journal of Nuclear Medicine

William E. Simon¹  Jeffry A. Siegel¹  Brian E. Zimmerman¹  Kory Kodimer¹  Mary A. Dell¹ 

关键词: ⁹⁰Y measurement;    dose calibrator;    ibritumomab tiuxetan;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

This investigation examined the accuracy of dose calibrator activity measurement of the β-emitting radiopharmaceutical 90Y-ibritumomab tiuxetan. Methods: Five different facilities independently measured 90Y in a 10-mL syringe geometry with 30 dose calibrator models from 3 different manufacturers. The activities ranged from 81.4 MBq (2.2 mCi) to 1,406 MBq (38 mCi) over the volume range of 3–9 mL. Results: The mean dial settings for 90Y measurement were 375, 51 × 10, and 897 × 100 for Atomlab, CRC, and Mark V dose calibrators, respectively. The maximum volume dependence was 0.28%/mL. Conclusion: This study demonstrated that when measuring all volumes of 90Y-ibritumomab tiuxetan activity prescriptions, only a single dial setting for a given manufacturer’s dose calibrator is required for accurate measurements. Volume corrections are not necessary. For best accuracy, an individually determined dial value should be used.

【 授权许可】

Unknown