Journal of Nuclear Medicine | |
Accurate Dose Calibrator Activity Measurement of 90Y-Ibritumomab Tiuxetan | |
William E. Simon1  Jeffry A. Siegel1  Brian E. Zimmerman1  Kory Kodimer1  Mary A. Dell1  | |
关键词: 90Y measurement; dose calibrator; ibritumomab tiuxetan; | |
DOI : | |
学科分类:医学(综合) | |
来源: Society of Nuclear Medicine | |
【 摘 要 】
This investigation examined the accuracy of dose calibrator activity measurement of the β-emitting radiopharmaceutical 90Y-ibritumomab tiuxetan. Methods: Five different facilities independently measured 90Y in a 10-mL syringe geometry with 30 dose calibrator models from 3 different manufacturers. The activities ranged from 81.4 MBq (2.2 mCi) to 1,406 MBq (38 mCi) over the volume range of 3–9 mL. Results: The mean dial settings for 90Y measurement were 375, 51 × 10, and 897 × 100 for Atomlab, CRC, and Mark V dose calibrators, respectively. The maximum volume dependence was 0.28%/mL. Conclusion: This study demonstrated that when measuring all volumes of 90Y-ibritumomab tiuxetan activity prescriptions, only a single dial setting for a given manufacturer’s dose calibrator is required for accurate measurements. Volume corrections are not necessary. For best accuracy, an individually determined dial value should be used.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010195857ZK.pdf | 551KB | download |